CEBPB Antibody

Size

100ug

Clone Number

Aliases

AGP/EBP antibody; C EBP beta antibody; C/EBP beta antibody; C/EBP related protein 2 antibody; CCAAT Enhancer Binding Protein beta antibody; CCAAT/enhancer-binding protein beta antibody; CEBPB antibody; CEBPB_HUMAN antibody; CRP2 antibody; IL 6DBP antibody; IL6DBP antibody; Interleukin 6 dependent binding protein antibody; LAP antibody; Liver activator protein antibody; Liver enriched transcriptional activator antibody; NF IL6 antibody; NFIL6 antibody; Nuclear factor NF IL6 antibody; Nuclear factor NF-IL6 antibody; SF B antibody; SFB antibody; Silencer factor B antibody; TCF-5 antibody; TCF5 antibody; Transcription factor 5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P17676

Immunogen

Recombinant Human CCAAT/enhancer-binding protein beta protein (41-270AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5\'-T[TG]NNGNAA[TG]-3\'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CEBPB

Research Areas

Others