CDYL2 Polyclonal Antibody

Ab type

Primary antibody

Background

CDY, a gene family expressed exclusively in the testis, localizes to a region of the Y chromosome frequently deleted in infertile males. CDY protein contains two functional domains, an N-terminal chromodomain, possibly functioning in heterochromatin interactions, and also a C-terminal domain which resembles enoyl-CoA-isomerase, a protein involved in fatty acid oxidation. Furthermore, CDY acts as a histone acetyltransferase, with strong preference for histone H4, a process required for the histone to proamine transition in spermatogenesis, consistent with the association with male infertility. Chromodomain Y-like protein (CDYL) is a related ubiquitous nuclear protein expressed at moderate levels in most tissues. The gene encoding for the CDYL protein localizes to chromosome 6p25.1.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CDYL2. AA range:31-80

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

56501

synonyms

CDYL2; Chromodomain Y-like protein 2; CDY-like 2