CDK5RAP2 Antibody

Size

100ug

Clone Number

Aliases

C48 antibody; CDK5 activator-binding protein C48 antibody; CDK5 regulatory subunit associated protein 2 antibody; CDK5 regulatory subunit-associated protein 2 antibody; CDK5RAP2 antibody; centrosomal protein 215 kDa antibody; Centrosome-associated protein 215 antibody; CEP215 antibody; CK5P2_HUMAN antibody; MCPH3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96SN8

Immunogen

Recombinant Human CDK5 regulatory subunit-associated protein 2 protein (996-1111AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes (PubMed:26485573).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CDK5RAP2

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cell biology; Tags & Cell Markers; Signal transduction