Cdk5(Phospho Tyr15) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family| the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein| which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons| functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization| endocytosis and exocytosis| and apoptosis. In humans| an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Reactivity

Human, Mouse, Rat, Monkey

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15. AA range:1-50

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

33304

synonyms

Cyclin-dependent kinase 5; CDK5; CDKN5; Cyclin-dependent kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit