CDH5 Antibody

Size

100ug

Clone Number

Aliases

7B 4 antibody; 7B4 antibody; 7B4 antigen antibody; CADH5_HUMAN antibody; Cadherin 5 antibody; Cadherin 5 type 2 antibody; Cadherin 5, type 2 (vascular endothelium) antibody; Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody; cadherin, vascular endothelial antibody; cadherin, vascular endothelial, 1 antibody; Cadherin-5 antibody; Cadherin5 antibody; CD 144 antibody; CD144 antibody; CD144 antigen antibody; CDH 5 antibody; CDH5 antibody; CDH5 protein antibody; Endothelial specific cadherin antibody; FLJ17376 antibody; OTTHUMP00000174777 antibody; Vascular endothelial cadherin antibody; Vascular epithelium cadherin antibody; VE Cad antibody; VE-cadherin antibody; VEC antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P33151

Immunogen

Recombinant Human Cadherin-5 protein (349-569AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CDH5

Research Areas

Cancer; Cardiovascular; Signal transduction