CD8A Monoclonal Antibody,Purified

Size

Clone Number

Aliases

Immunogen Species

Human

UniProt ID

P01732

Immunogen

Recombinant Protein

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,FC

Background

COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.1. Engleman EG et al. (1981) J Exp Med  153: 193-198.2. Haynes,B et al. (1986) Leukocyte TypingII: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science 274:1906

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD8A

Research Areas

Immunology