CD79A Monoclonal Antibody

Size

100ul

Clone Number

Aliases

B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a), CD79A, IGA MB1

Immunogen Species

Homo sapiens (Human)

UniProt ID

P11912

Immunogen

Synthesized peptide derived from human CD79a

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Clonality

Monoclonal

Isotype

IgG2a, Kappa

Purification Method

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugate

Non-conjugated

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD79A

Research Areas

Immunology