CD33 Antibody

Size

100ul

Clone Number

Aliases

CD 33 antibody; CD33 antibody; CD33 antigen (gp67) antibody; CD33 antigen antibody; CD33 molecule antibody; CD33_HUMAN antibody; FLJ00391 antibody; gp67 antibody; My9 antibody; Myeloid cell surface antigen CD33 antibody; Myeloid cell surface antigen CD33 precursor antibody; Myeloid differentiation antigen CD33 antibody; p67 antibody; Sialic acid binding Ig like lectin 3 antibody; Sialic acid binding immunoglobulin like lectin 3 antibody; Sialic acid-binding Ig-like lectin 3 antibody; SIGLEC 3 antibody; Siglec-3 antibody; SIGLEC3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P20138

Immunogen

Recombinant Human Myeloid cell surface antigen CD33 protein (49-259AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD33

Research Areas

Immunology; Stem cells