CD22 Antibody

Size

100ul

Clone Number

Aliases

B cell receptor CD22 precursor antibody; B lymphocyte cell adhesion molecule antibody; B-cell receptor CD22 antibody; B-lymphocyte cell adhesion molecule antibody; BL CAM antibody; BL-CAM antibody; BLCAM antibody; CD 22 antibody; CD22 antibody; CD22 antigen antibody; CD22 molecule antibody; CD22 protein antibody; CD22_HUMAN antibody; Lectin 2 antibody; Leu14 antibody; Lyb8 antibody; MGC130020 antibody; sialic acid binding Ig like lectin 2 antibody; Sialic acid binding immunoglobulin like lectin 2 antibody; Sialic acid-binding Ig-like lectin 2 antibody; SIGLEC 2 antibody; Siglec-2 antibody; SIGLEC2 antibody; T cell surface antigen Leu 14 antibody; T-cell surface antigen Leu-14 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P20273

Immunogen

Recombinant Human B-cell receptor CD22 protein (708-847AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD22

Research Areas

Cancer; Immunology; Stem cells