CD207 Antibody

Size

100ug

Clone Number

Aliases

C type lectin domain family 4 member K antibody; C-type lectin domain family 4 member K antibody; CD 207 antibody; CD207 antibody; CD207 antigen antibody; CD207 antigen; langerin antibody; CD207 molecule antibody; CLC4K_HUMAN antibody; CLEC 4K antibody; CLEC4K antibody; Langerhans cell specific c type lectin antibody; Langerin antibody; RGD1565913 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UJ71

Immunogen

Recombinant Human C-type lectin domain family 4 member K protein (229-312AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD207

Research Areas

Tags & Cell Markers; Signal transduction