CD146 Monoclonal Antibody

Size

100ul

Clone Number

4D10C7

Aliases

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146), MCAM, MUC18

Immunogen Species

Human

UniProt ID

P43121

Immunogen

Recombinant Human Cell surface glycoprotein MUC18 protein (50-646AA)

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA, WB, IF, FC; Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200

Background

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Clonality

Monoclonal

Isotype

IgG2a

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CD146

Research Areas

Immunology