CCP110 Antibody

Size

100ul

Clone Number

Aliases

110 kDa centrosomal protein antibody; CCP110 antibody; Centriolar coiled coil protein 110kDa antibody; Centrosomal protein 110 kDa antibody; Centrosomal protein CP110 antibody; Centrosomal protein of 110 kDa antibody; Cep110 antibody; CP110 antibody; CP110_HUMAN antibody; DKFZp781G1416 antibody; FAN antibody; KIAA0419 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43303

Immunogen

Recombinant Human Centriolar coiled-coil protein of 110 kDa protein (1-280AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CCP110

Research Areas

Cancer; Cell biology; Tags & Cell Markers