CBFA2T2 Antibody

Size

100ul

Clone Number

Aliases

AML1 MTG8 antibody; cbfa2t2 antibody; Core binding factor runt domain alpha subunit 2 translocated to 2 antibody; core-binding factor; runt domain; alpha subunit 2 antibody; DKFZp313F2116 antibody; EHT antibody; ETO homolog on chromosome 20 antibody; ETO homologous on chromosome 20 antibody; MTG 8 like protein antibody; MTG 8 related protein 1 antibody; MTG8 like protein antibody; MTG8 related protein 1 antibody; MTG8-like protein antibody; MTG8-related protein 1 antibody; MTG8R_HUMAN antibody; MTGR 1 antibody; Myeloid translocation gene related protein 1 antibody; Myeloid translocation related protein 1 antibody; Myeloid translocation-related protein 1 antibody; p85 antibody; Protein CBFA2T2 antibody; ZMYND 3 antibody; ZMYND3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43439

Immunogen

Recombinant Human Protein CBFA2T2 protein (325-604AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CBFA2T2

Research Areas

Tags & Cell Markers