Cathepsin L Polyclonal Antibody

Ab type

Primary antibody

Background

Cathepsin L1 encoded by CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human Cathepsin L.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

37564

synonyms

CTSL1; CTSL; Cathepsin L1; Major excreted protein; MEP