CAMK2B Antibody

Size

100ul

Clone Number

Aliases

Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody; Calcium/calmodulin dependent protein kinase II beta antibody; Calcium/calmodulin dependent protein kinase IIB antibody; Calcium/calmodulin dependent protein kinase type II beta chain antibody; calcium/calmodulin-dependent protein kinase II beta antibody; Calcium/calmodulin-dependent protein kinase type II subunit beta antibody; CAM 2 antibody; CaM kinase II beta chain antibody; CaM kinase II beta subunit antibody; CaM kinase II subunit beta antibody; CaM-kinase II beta chain antibody; CAM2 antibody; CAMK 2 antibody; CAMK 2B antibody; CaMK II beta subunit antibody; CaMK II subunit beta antibody; CaMK-II subunit beta antibody; CAMK2 antibody; CaMK2 beta antibody; Camk2b antibody; CAMKB antibody; CaMKII beta subunit antibody; CaMKIIB antibody; KCC2B_HUMAN antibody; MGC29528 antibody; Proline rich calmodulin dependent protein kinase antibody; proline rich calmodulin-dependent protein kinase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13554

Immunogen

Recombinant Human Calcium/calmodulin-dependent protein kinase type II subunit beta protein (1-300AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CAMK2B

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cell biology; Signal transduction