CAMK1 Antibody

Size

100ug

Clone Number

Aliases

Calcium / calmodulin dependent protein kinase 1 antibody; Calcium / calmodulin dependent protein kinase I antibody; Calcium / calmodulin dependent protein kinase type 1 antibody; Calcium/calmodulin dependent protein kinase 1 antibody; Calcium/calmodulin dependent protein kinase I antibody; Calcium/calmodulin dependent protein kinase type 1 antibody; Calcium/calmodulin-dependent protein kinase type 1 antibody; CaM K1 antibody; CaM KI antibody; CaM kinase 1 alpha antibody; CAM kinase 1 antibody; CaM kinase I alpha antibody; CaM kinase I antibody; CaM-KI antibody; CaMK 1 antibody; CAMK I antibody; CaMK1 alpha antibody; CAMK1 antibody; CAMK1 PEN antibody; CaMKI alpha antibody; CaMKI-alpha antibody; KCC1A_HUMAN antibody; MGC120317 antibody; MGC120318 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14012

Immunogen

Recombinant Human Calcium/calmodulin-dependent protein kinase type 1 protein (166-265AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \\\'Ser-694\\\', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \\\'Ser-91\\\', \\\'Ser-92\\\', \\\'Ser-93\\\' and \\\'Ser-294\\\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \\\'Ser-259\\\' and \\\'Ser-498\\\' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on \\\'Ser-276\\\' and \\\'Ser-295\\\'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CAMK1

Research Areas

Neuroscience; Cardiovascular; Signal transduction