Caldesmon Polyclonal Antibody

Ab type

Primary antibody

Background

CALD1 (caldesmon 1) encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Caldesmon. AA range:744-793

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60

synonyms

CALD1; CAD; CDM; Caldesmon; CDM