CADM1 Antibody

Size

100ul

Clone Number

Aliases

BL2 antibody; Cadm1 antibody; CADM1_HUMAN antibody; Cell adhesion molecule 1 antibody; DKFZp686F1789 antibody; IgSF4 antibody; IGSF4A antibody; Immunoglobulin superfamily member 4 antibody; MGC149785 antibody; MGC51880 antibody; NECL-2 antibody; NECL2 antibody; Nectin like 2 antibody; Nectin-like protein 2 antibody; RA175 antibody; SgIGSF antibody; Spermatogenic immunoglobulin superfamily antibody; ST17 antibody; sTSLC 1 antibody; Synaptic cell adhesion molecule antibody; SynCAM antibody; SynCAM1 antibody; TSLC-1 antibody; TSLC1 antibody; Tumor suppressor in lung cancer 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BY67

Immunogen

Recombinant Human Cell adhesion molecule 1 protein (45-344AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CADM1

Research Areas

Neuroscience; Signal transduction