CAD(phospho-Ser1859) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II)| aspartate transcarbamoylase| and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade| which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human CAD (Ser1859)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

CAD ;Ser1859 ; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase; EC 6.3.5.5; Aspartate carbamoyltransferase; EC 2.1.3.2; Dihydroorotase; EC 3.5.2.3;