CACNA1H Antibody

Size

100ug

Clone Number

Aliases

Alpha1 3.2 antibody; Alpha13.2 antibody; CAC1H_HUMAN antibody; CACNA 1H antibody; CACNA1 H antibody; CACNA1 HB antibody; Cacna1h antibody; CACNA1HB antibody; Calcium channel alpha13.2 subunit antibody; Calcium channel voltage dependent T type alpha 1H subunit antibody; Calcium channel; voltage-dependent; T type; alpha 1Hb subunit antibody; Cav 3.2 antibody; Cav T.2 antibody; Cav3.2 antibody; CavT.2 antibody; EIG 6 antibody; EIG6 antibody; Low voltage activated calcium channel alpha 13.2 subunit antibody; Low voltage activated calcium channel alpha1 3.2 subunit antibody; Low-voltage-activated calcium channel alpha1 3.2 subunit antibody; MNCb 1209 antibody; T type Cav3.2 antibody; Voltage dependent t type calcium channel alpha 1H subunit antibody; Voltage gated calcium channel alpha subunit Cav 3.2 antibody; Voltage gated calcium channel alpha subunit Cav T.2 antibody; Voltage gated calcium channel alpha subunit Cav3.2 antibody; Voltage gated calcium channel alpha subunit CavT.2 antibody; Voltage-dependent T-type calcium channel subunit alpha-1H antibody; Voltage-gated calcium channel subunit alpha Cav3.2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O95180

Immunogen

Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H protein (260-360AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the \\\"low-voltage activated (LVA)\\\" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CACNA1H

Research Areas

Neuroscience; Signal transduction