CACNA1C Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1| alpha-2/delta| beta| and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins| either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human CACNA1C

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

244310

synonyms

CACNA1C; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2