CACNA1C Antibody

Size

100ug

Clone Number

Aliases

alpha-1 polypeptide antibody; cardiac muscle antibody; isoform 1 antibody; L type antibody; CAC1C_HUMAN antibody; CACH 2 antibody; CACH2 antibody; CACN 2 antibody; CACN2 antibody; CACNA1C antibody; CACNL1A1 antibody; Calcium channel antibody; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit antibody; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle antibody; Calcium channel voltage dependent L type alpha 1C subunit antibody; CaV1.2 antibody; CCHL1A1 antibody; DHPR alpha 1 antibody; DHPR alpha 1 subunit antibody; LQT8 antibody; TS antibody; Voltage dependent L type calcium channel alpha 1C subunit antibody; Voltage dependent L type calcium channel subunit alpha 1C antibody; Voltage gated calcium channel alpha subunit Cav1.2 antibody; Voltage gated calcium channel subunit alpha Cav1.2 antibody; Voltage gated L type calcium channel Cav1.2 alpha 1 subunit; splice variant 10* antibody; Voltage-dependent L-type calcium channel subunit alpha-1C antibody; Voltage-gated calcium channel subunit alpha Cav1.2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13936

Immunogen

Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500

Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the \\\'high-voltage activated\\\' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CACNA1C

Research Areas

Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction