BVES Antibody

Size

100ul

Clone Number

Aliases

Blood vessel epicardial substance antibody; Bves antibody; hBVES antibody; MGC42413 antibody; POP 1 antibody; POP1 antibody; POPD1_HUMAN antibody; POPDC 1 antibody; POPDC1 antibody; Popeye domain containing 1 antibody; Popeye domain containing protein 1 antibody; Popeye domain-containing protein 1 antibody; Popeye protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8NE79

Immunogen

Recombinant Human Blood vessel epicardial substance protein (241-360AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BVES

Research Areas

Signal transduction