BRSK1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

BR serine/threonine kinase 1 antibody; BR serine/threonine protein kinase 1 antibody; BR serine/threonine-protein kinase 1 antibody; Brain selective kinase 1 antibody; Brain-specific serine/threonine-protein kinase 1 antibody; BRSK 1 antibody; Brsk1 antibody; BRSK1_HUMAN antibody; FLJ43009 antibody; hSAD1 antibody; KIAA1811 antibody; Protein kinase SAD1A antibody; SAD 1 antibody; SAD1 antibody; SAD1 homolog antibody; SAD1 kinase antibody; SAD1A antibody; SADB antibody; SadB kinase short isoform antibody; Serine/threonine kinase SAD B antibody; Serine/threonine-protein kinase SAD-B antibody; Synapses of Amphids Defective homolog antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8TDC3

Immunogen

Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at \'Thr-529\' and \'Ser-579\'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at \'Ser-642\' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at \'Ser-131\', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BRSK1

Research Areas

Cell biology