BRD7 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

75 kDa bromodomain protein antibody; BP75 antibody; BRD 7 antibody; BRD7 antibody; BRD7_HUMAN antibody; Bromodomain containing 7 antibody; bromodomain containing protein 7 antibody; Bromodomain-containing protein 7 antibody; CELTIX 1 antibody; CELTIX1 antibody; NAG4 antibody; Protein CELTIX-1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NPI1

Immunogen

Recombinant Human Bromodomain-containing protein 7 protein (601-651AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at \\\'Tyr-216\\\'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at \\\'Lys-9\\\' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at \\\'Lys-382\\\', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BRD7

Research Areas

Epigenetics and Nuclear Signaling; Cell biology