BRAP Antibody

Size

100ug

Clone Number

Aliases

BRAP antibody; RNF52BRCA1-associated protein antibody; EC 2.3.2.27 antibody; BRAP2 antibody; Impedes mitogenic signal propagation antibody; IMP antibody; RING finger protein 52 antibody; RING-type E3 ubiquitin transferase BRAP2 antibody; Renal carcinoma antigen NY-REN-63 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q7Z569

Immunogen

Recombinant Human BRCA1-associated protein (13-124AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200

Background

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BRAP

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction