BMP-6 Polyclonal Antibody

Ab type

Primary antibody

Background

BMP6 (bone morphogenetic protein 6) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of BMP6 may be associated with progression of breast and prostate cancer. Mutations in BMP6 may be associated with iron overload in human patients.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human BMP-6. AA range:103-152

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

57226

synonyms

BMP6; VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1