BIRC7 Antibody

Size

100ul

Clone Number

Aliases

Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney inhibitor of apoptosis protein antibody; Livin antibody; Livin inhibitor of apotosis antibody; Melanoma inhibitor of apoptosis protein antibody; ML IAP antibody; ML-IAP antibody; MLIAP antibody; RING finger protein 50 antibody; RNF 50 antibody; RNF50 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96CA5

Immunogen

Recombinant Human Baculoviral IAP repeat-containing protein 7 protein (1-265AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:200-1:1000

Background

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BIRC7

Research Areas

Cancer; Cell biology