BIRC3 Antibody

Size

100ug

Clone Number

Aliases

AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; Baculoviral IAP repeat containing 3 antibody; Baculoviral IAP repeat containing protein 3 antibody; Baculoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_HUMAN antibody; C IAP2 antibody; C-IAP2 antibody; Cellular inhibitor of apoptosis 2 antibody; cellular inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13489

Immunogen

Recombinant Human Baculoviral IAP repeat-containing protein 3 protein (76-245AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BIRC3

Research Areas

Cancer; Cell biology; Metabolism