BICD2 Antibody

Size

100ug

Clone Number

Aliases

bA526D8.1 antibody; Bic D 2 antibody; Bic-D 2 antibody; Bicaudal D homolog 2 (Drosophila) antibody; Bicaudal D homolog 2 antibody; Bicd2 antibody; BICD2_HUMAN antibody; Coiled coil protein BICD2 antibody; Cytoskeleton like bicaudal D protein homolog 2 antibody; Homolog of Drosophila bicaudal D antibody; KIAA0699 antibody; Protein bicaudal D homolog 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8TD16

Immunogen

Recombinant Human Protein bicaudal D homolog 2 protein (511-625AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200

Background

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BICD2

Research Areas

Signal transduction