Bcl-7a Polyclonal Antibody

Ab type

Primary antibody

Background

BCL7A (BCL tumor suppressor 7A) is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for BCL7A.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

22810

synonyms

BCL7A; B-cell CLL/lymphoma 7 protein family member A