BBS9 Antibody

Size

100ug

Clone Number

Aliases

B1 antibody; Bardet Biedl syndrome 9 antibody; Bardet-Biedl syndrome 9 protein antibody; bbs9 antibody; C18 antibody; D1 antibody; MGC118917 antibody; OTTHUMP00000158833 antibody; OTTHUMP00000202918 antibody; OTTHUMP00000202919 antibody; OTTHUMP00000202920 antibody; Parathyroid hormone-responsive B1 gene protein antibody; Protein PTHB1 antibody; PTH-responsive osteosarcoma B1 protein antibody; PTHB1 antibody; PTHB1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q3SYG4

Immunogen

Recombinant Human Protein PTHB1 protein (8-185AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

BBS9

Research Areas

Neuroscience; Metabolism; Signal transduction