AZU1 Antibody

Size

100ul

Clone Number

Aliases

Azu 1 antibody; AZU1 antibody; Azurocidin antibody; CAP37 antibody; CAP7_HUMAN antibody; Cationic antimicrobial protein 37 antibody; Cationic antimicrobial protein CAP37 antibody; HBP antibody; Heparin binding protein antibody; Heparin-binding protein antibody; HUMAZUR antibody; Neutrophil azurocidin antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P20160

Immunogen

Recombinant Human Azurocidin protein (27-251AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AZU1

Research Areas

Cardiovascular; Immunology; Microbiology