AXL Antibody

Size

100ug

Clone Number

Aliases

Adhesion related kinase antibody; AI323647 antibody; Ark antibody; Axl antibody; AXL oncogene antibody; AXL receptor tyrosine kinase antibody; AXL transforming gene antibody; AXL transforming sequence/gene antibody; EC 2.7.10.1 antibody; JTK11 antibody; Oncogene AXL antibody; Tyro7 antibody; Tyrosine protein kinase receptor UFO antibody; Tyrosine-protein kinase receptor UFO antibody; UFO antibody; UFO_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P30530

Immunogen

Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AXL

Research Areas

Cancer; Cell biology; Tags & Cell Markers; Signal transduction