AURKC Antibody

Size

100ug

Clone Number

Aliases

AURKC antibody; AIE 2 antibody; Aie1 antibody; AIE2 antibody; AIK 3 antibody; AIK3 antibody; ARK 3 antibody; ARK-3 antibody; ARK3 antibody; Aur C antibody; AurC antibody; Aurkc antibody; AURKC_HUMAN antibody; aurora 3 antibody; Aurora C antibody; Aurora kinase C antibody; aurora related kinase 3 antibody; Aurora-related kinase 3 antibody; Aurora/Ipl1 related kinase 3 antibody; Aurora/Ipl1-related kinase 3 antibody; Aurora/Ipl1/Eg2 protein 2 antibody; EC 2.7.11.1 antibody; Serine threonine protein kinase 13 antibody; serine/threonine kinase 13 (aurora/IPL1 like) antibody; serine/threonine protein kinase aurora C antibody; Serine/threonine-protein kinase 13 antibody; Serine/threonine-protein kinase aurora-C antibody; SPGF5 antibody; STK13 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UQB9

Immunogen

Recombinant Human Aurora kinase C protein (12-143AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at \\\'Ser-10\\\' and \\\'Ser-28\\\'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at \\\'Ser-228\\\'.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

AURKC

Research Areas

Cell biology