ATP8B1 Antibody

Size

100ug

Clone Number

Aliases

AT8B1_HUMAN antibody; ATP8B1 antibody; ATPase class I type 8B member 1 antibody; ATPase; aminophospholipid transporter; class I; type 8B; member 1 antibody; ATPIC antibody; BRIC antibody; E1-E2 ATPase antibody; Familial intrahepatic cholestasis type 1 antibody; FIC1 antibody; OTTHUMP00000163615 antibody; PFIC antibody; PFIC1 antibody; Phospholipid transporting ATPase IC antibody; Probable phospholipid-transporting ATPase IC antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43520

Immunogen

Recombinant Human Phospholipid-transporting ATPase IC protein (217-330AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ATP8B1

Research Areas

Signal transduction