ATP8A2 Antibody

Size

100ug

Clone Number

Aliases

AT8A2_HUMAN antibody; ATP antibody; Atp8a2 antibody; ATPase aminophospholipid transporter class I type 8A member 2 antibody; ATPase aminophospholipid transporter like class I type 8A member 2 antibody; ATPase class I type 8A member 2 antibody; ATPase phospholipid transporting 8A2 antibody; ATPIB antibody; CAMRQ4 antibody; EC=3.6.3.1 antibody; IB antibody; ML-1 antibody; ML1 antibody; P4 ATPase flippase complex alpha subunit ATP8A2 antibody; Probable phospholipid-transporting ATPase IB antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NTI2

Immunogen

Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ATP8A2

Research Areas

Others