ATP7A Polyclonal Antibody

Ab type

Primary antibody

Background

ATP7A (ATPase copper transporting alpha) encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in ATP7A are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human ATP7A. AA range:591-640

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

163335/165110/172078/154357

synonyms

ATP7A; MC1; MNK; Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein