Atm Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from Atm . at AA range: 1920-2000

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

350644

synonyms

ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated