ASPN Antibody

Size

100ug

Clone Number

Aliases

ASPN antibody; ASPN protein antibody; ASPN_HUMAN antibody; Asporin (LRR class 1) antibody; Asporin antibody; Asporin proteoglycan antibody; FLJ20129 antibody; LRR class 1 antibody; Periodontal ligament associated protein 1 antibody; Periodontal ligament-associated protein 1 antibody; PLAP 1 antibody; PLAP-1 antibody; PLAP1 antibody; SLRR 1C antibody; SLRR1C antibody; Small leucine rich protein 1C antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BXN1

Immunogen

Recombinant Human Asporin protein (33-380AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ASPN

Research Areas

Signal transduction