ASK1(Phospho Thr838) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838| inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to| and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.|Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6| which in turn activate the JNK and p38 MAP kinases| respectively. Overexpression induces apoptotic cell death.|induction:By TNF-alpha. Inhibited by HIV-1 Nef.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|Contains 1 protein kinase domain.|subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.|tissue specificity:Abundantly expressed in heart and pancreas.|

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human ASK1 (Phospho Thr838)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

151140

synonyms

ASK1 ;Phospho Thr838; Mitogen-activated protein kinase kinase kinase 5; EC 2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5