ASIP Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

ASIP antibody; AGTI antibody; AGTIL antibody; ASP antibody; Agouti-signaling protein antibody; ASP antibody; Agouti switch protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P42127

Immunogen

Recombinant Human Agouti-signaling protein (23-112AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ASIP

Research Areas

Neuroscience; Signal transduction