Arkadia Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

108876

synonyms

RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111