ARFGEF2 Antibody

Size

100ug

Clone Number

Aliases

ARFGEF2 antibody; ARFGEP2 antibody; BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody; Brefeldin A-inhibited GEP 2 antibody; ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y6D5

Immunogen

Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 protein (200-317AA)

Raised in

Rabbit

Species Reactivity

Human, Rat, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ARFGEF2

Research Areas

Neuroscience; Signal transduction