APTX Antibody

Size

100ug

Clone Number

Aliases

AOA 1 antibody; AOA antibody; AOA1 antibody; Aprataxin antibody; Aprataxin homolog antibody; Aptx antibody; APTX_HUMAN antibody; Ataxia 1 early onset with hypoalbuminemia antibody; Ataxia1 early onset with hypoalbuminemia antibody; AXA 1 antibody; AXA1 antibody; EAOH antibody; EOAHA antibody; FHA HIT antibody; FHA-HIT antibody; FLJ20157 antibody; Forkhead associated domain histidine triad like antibody; Forkhead associated domain histidine triad like protein antibody; Forkhead-associated domain histidine triad-like protein antibody; MGC1072 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q7Z2E3

Immunogen

Recombinant Human Aprataxin protein (92-161AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5\'-phosphate termini, resulting in the production of 5\'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5\'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

APTX

Research Areas

Epigenetics and Nuclear Signaling