APOO Antibody

Size

100ul

Clone Number

Aliases

0610008C08Rik antibody; 1110019O03Rik antibody; Apolipoprotein O antibody; APOO antibody; APOO_HUMAN antibody; FAM121B antibody; Family with sequence similarity 121B antibody; MGC130105 antibody; MGC130106 antibody; MGC4825 antibody; My025 antibody; MYO25 antibody; OTTHUMP00000023073 antibody; Protein FAM121B antibody; RP23-272D10.2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BUR5

Immunogen

Recombinant Human MICOS complex subunit MIC26 protein (26-198AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

APOO

Research Areas

Signal Transduction