APOBEC3F Antibody

Size

100ug

Clone Number

Aliases

A3F antibody; ABC3F_HUMAN antibody; APOBEC3F antibody; Apolipoprotein B mRNA editing enzyme; catalytic polypeptide like 3F antibody; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F antibody; ARP8 antibody; DNA dC->dU-editing enzyme APOBEC-3F antibody; Induced upon T cell activation antibody; KA6 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IUX4

Immunogen

Recombinant Human DNA dC->dU-editing enzyme APOBEC-3F protein (139-287AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

APOBEC3F

Research Areas

Others