APOB Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms| apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single| very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA)| resulting in the creation of a stop codon| and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia| normotriglyceridemic hypobetalipoproteinemia| and hypercholesterolemia due to ligand-defective apoB| diseases affecting plasma cholesterol and apoB levels.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human APOB

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

501930

synonyms

APOB; Apolipoprotein B-100; Apo B-100; Apolipoprotein B-48; Apo B-48;