APC Polyclonal Antibody

Ab type

Primary antibody

Background

APC encodes a tumor suppressor protein (APC, WNT signaling pathway regulator) that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in APC cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human APC. AA range:2794-2843

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

311646

synonyms

APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5