APC Antibody

Size

100ul

Clone Number

5F2

Aliases

Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5

Immunogen Species

Homo sapiens (Human)

UniProt ID

P25054

Immunogen

A synthesized peptide derived from human APC

Raised in

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Background

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Clonality

Monoclonal

Isotype

Rabbit IgG

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

APC

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cardiovascular; Cell biology; Stem cells